Myocyte Enhancer Factor-2A Gene Mutation and Coronary Artery Disease
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چکیده
منابع مشابه
Myocyte Enhancer Factor-2A Gene Mutation and Coronary Artery Disease
BACKGROUND Premature ventricular contractions (PVCs) are common in the general population, and frequent PVCs may result in the poor quality of life or even the damage of cardiac function. We examined the efficacy and safety of a traditional Chinese medicine Wenxin Keli for the treatment of frequent PVCs among a relatively large Chinese cohort. METHODS We performed a randomized, double-blind, ...
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MEF2 (myocyte enhancer factor 2) proteins are a small family of transcription factors that play pivotal roles in striated muscle differentiation, development, and metabolism, in neuron survival and synaptic formation, and in lymphocyte selection and activation. Products of the four mammalian MEF2 genes, MEF2A, MEF2B, MEF2C, and MEF2D, are expressed with overlapping but distinct temporospatial p...
متن کاملMOLECULAR STUDY OF E148Q MUTATION IN EXON 2 OF MEFV GENE IN PATIENTS WITH PREMATURE CORONARY ARTERY DISEASE
Background & Aims: Recent studies have shown that some of the MEFV gene mutations are common in patients with coronary artery disease. The present study was designed to investigate the presence or absence of E148Q mutation in exon 2 of MEFV gene in patients with premature coronary artery disease. Materials & Methods: In this study, 90 patients with coronary artery disease were voluntarily sele...
متن کاملThe Effect of Myocyte Enhancer Factor 2A Gene on proliferation, migration and phenotype of Vascular Smooth Muscle Cells
Aims: The genetic basis for vascular smooth muscle cells (VSMCs) phenotypic switching is unclear. Recent studies showed that 21-base pair deletion mutation (△21) in myocyte enhancer factor 2A (MEF2A) gene could be an inherited marker for coronary artery disease. The effect of MEF2A gene mutation on the VSMCs phenotypic switching was studied. Methods: Human aortic VSMCs were used. Four groups VS...
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ژورنال
عنوان ژورنال: Chinese Medical Journal
سال: 2015
ISSN: 0366-6999
DOI: 10.4103/0366-6999.166021